%0 Journal Article %A TORU BEPPU %A YASUNORI EMI %A SHOJI TOKUNAGA %A EIJI OKI %A KEN SHIRABE %A SHINICHI UENO %A MASAFUMI KURAMOTO %A AKIRA KABASHIMA %A IKUO TAKAHASHI %A HIRONORI SAMURA %A SUSUMU EGUCHI %A YOSHITO AKAGI %A SHOJI NATSUGOE %A YUTAKA OGATA %A YOSHIHIRO KAKEJI %A HIDEO BABA %A YOSHIHIKO MAEHARA %A KYUSHU STUDY GROUP OF CLINICAL CANCER (KSCC) %T Liver Resectability of Advanced Liver-limited Colorectal Liver Metastases Following mFOLFOX6 with Bevacizumab (KSCC0802 Study) %D 2014 %J Anticancer Research %P 6655-6662 %V 34 %N 11 %X Background/Aim: The Kyushu Study group of Clinical Cancer (KSCC) conducted phase II trials (KSCC0802 - UMIN000001308) concerning liver resectability after first-line treatment of advanced liver-limited colorectal metastases (CRLM) by a prospective, multi-center study. Patients and Methods: Patients received 6 cycles of mFOLFOX6 with bevacizumab followed by evaluating liver resectability. The primary end-point was liver resection rate. Results: The 40 patients enrolled from September 2008 to August 2010. The median number of administration cycles was 6 (range=1-7). The liver resectability cases were 16/40 (40.0 %) and the number of R0 cases was 10 patients (25.0%). An overall response rate was 30.0% (95% CI=15.2%-44.8%). Median progression-free and overall survival of all patients was 9.7 months and 33.0 months), respectively. Conclusion: mFOLFOX6 with bevacizumab regimen is safe and effective for advanced liver-limited CRLM and might lead to high liver resectability. %U https://ar.iiarjournals.org/content/anticanres/34/11/6655.full.pdf