PT - JOURNAL ARTICLE AU - EMMA LACHAIER AU - CHRISTOPHE LOUANDRE AU - CORINNE GODIN AU - ZUZANA SAIDAK AU - MAXIME BAERT AU - MOMAR DIOUF AU - BRUNO CHAUFFERT AU - ANTOINE GALMICHE TI - Sorafenib Induces Ferroptosis in Human Cancer Cell Lines Originating from Different Solid Tumors DP - 2014 Nov 01 TA - Anticancer Research PG - 6417--6422 VI - 34 IP - 11 4099 - http://ar.iiarjournals.org/content/34/11/6417.short 4100 - http://ar.iiarjournals.org/content/34/11/6417.full SO - Anticancer Res2014 Nov 01; 34 AB - Background/Aim: Ferroptosis is a recently identified form of regulated necrosis that can be experimentally induced in cancer cells with the chemical inducer erastin. Recently, we identified sorafenib, an inhibitor of oncogenic kinases, as an inducer of ferroptosis in hepatocellular carcinoma cells. Whether sorafenib is able to exert its ferroptotic activity in cancer cells originating from other tissues is presently unclear. Materials and Methods: We compared the levels of ferroptosis induced by sorafenib with those induced by the reference compound erastin in a panel of ten human cell lines originating from various tissues. Results: Sorafenib induced ferroptosis in different cancer cell lines. We found a positive correlation between the ferroptotic potency of sorafenib and erastin. Compared to other kinase inhibitors, sorafenib is the only drug that displays ferroptotic efficacy. Conclusion: The findings establish sorafenib as the first clinically-approved anticancer drug that can induce ferroptosis.