TY - JOUR T1 - HPV16-L1-specific Antibody Response Is Associated with Clinical Remission of High-risk HPV-positive Early Dysplastic Lesions JF - Anticancer Research JO - Anticancer Res SP - 5127 LP - 5132 VL - 34 IS - 9 AU - GRIT MEHLHORN AU - SIMONE K. HAUTMANN AU - MARTIN C. KOCH AU - JOHANNA D. STREHL AU - ARNDT HARTMANN AU - RALF HILFRICH AU - MATTHIAS W. BECKMANN AU - HENRIK GRIESSER Y1 - 2014/09/01 UR - http://ar.iiarjournals.org/content/34/9/5127.abstract N2 - Background/Aim: The present study was aimed at clarifying if use of a rapid human papillomavirus type 16 L1-specific antibody test could be used to improve clinical management of high-risk HPV-positive low-grade squamous intraepithelial lesion (LSIL)/high-grade squamous intraepithelial lesion (HSIL). Patients and Methods: The study was nested within a prospective study of 801 patients with early dysplastic high-risk HPV-positive lesions to examine the prognostic significance of HPV-L1 protein detection. Serum samples of 87 patients were tested with a rapid HPV16-L1-specific antibody test. The results were correlated with the clinical outcome during 66 months of follow-up. Results: A combined analysis of the 22 antibody-positive women showed that 17 were also L1 protein-positive, and 5 were L1 capsid protein-negative. An HPV-specific immune competence strongly correlates with clinical remission of low-grade squamous intraepithelial lesion (76.6%). For L1 antigen and HPV16-L1 antibody double-positive women, the risk of progression to cervical intraepithelial neoplasia grade 3 was low (5.8%). Conclusion: The rapid anti-HPV16-L1 test could be a promising tool to improve risk assessment and appropriate clinical management of high-risk HPV-positive early dysplastic lesions. ER -