RT Journal Article
SR Electronic
T1 A Tertiary Sulfonium Compound, Dimethylsulfoniopropionate in Green Sea Algae, Completely Suppresses Crucial Ehrlich Ascites Carcinoma in Mice
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4045
OP 4050
VO 34
IS 8
A1 KENJI NAKAJIMA
A1 SATOMI TSUJIWAKI
A1 YOSHIKI NAKAJIMA
YR 2014
UL http://ar.iiarjournals.org/content/34/8/4045.abstract
AB Background/Aim: Dimethylsulfoniopropionate (DMSP) has been intensively studied in bacteria, plankton, algae and salt-resistant plants to investigate its metabolism and fate in the atmosphere. However, its effects on diseased terrestrial animals have not yet been examined. We have found that DMSP exerts a great healing effect for a variety of inflammatory disorders in rodents. In the present study, effects of single and high concentration of DMSP on terrible Ehrlich ascites carcinoma (EAC) bearing-mice with unavoidable-rapid death were examined. Results: We found that high concentration of DMSP completely suppresses acute EAC, which has never been eradicated, and accumulates large amounts of activated macrophages with no inflammation on various viscera in the peritoneal cavity of normal mice. Conclusion: These results show that DMSP is a new and potent anticancer compound with no side-effects, most likely playing a vital role for cancer immune therapy.