TY - JOUR T1 - Effects of Chemoradiotherapy on Lymph Nodes in Patients with Rectal Adenocarcinoma: Evaluation of Numbers and Sizes of Retrieved Lymph Nodes Inside and Outside the Radiation Field JF - Anticancer Research JO - Anticancer Res SP - 4195 LP - 4200 VL - 34 IS - 8 AU - KAZUTAKE OKADA AU - SOTARO SADAHIRO AU - TOSHIYUKI SUZUKI AU - AKIRA TANAKA AU - GOTA SAITO AU - AKEMI KAMIJO AU - TAKESHI AKIBA AU - SHUICHI KAWADA Y1 - 2014/08/01 UR - http://ar.iiarjournals.org/content/34/8/4195.abstract N2 - Background: Preoperative chemoradiotherapy (CRT) decreases the number of retrieved lymph nodes (LNs) in rectal cancer. LNs inside the irradiation field are affected by CRT, whereas those outside the irradiation field are affected only by concurrent chemotherapy. Patients and Methods: The study cohort comprised of 210 patients with clinical stage II/III rectal adenocarcinoma. One hundred and eight received surgery alone (S group), and 102 received preoperative CRT (40 or 45 Gy) with concurrent oral UFT or S-1 uracil/tegafur or S-1 (CRT group). Results: The number of LNs inside the irradiation field was significantly smaller in the CRT group (4±4) than in the S group (6±6, p<0.01), but the number of LNs outside the irradiation field did not differ (5±4 in both groups). The longest diameters of LNs in the S group were significantly smaller than those of the CRT group both inside and outside the irradiation fields (p<0.01). Conclusion: The effects of CRT on LNs in patients with rectal adenocarcinoma differed inside and outside the radiation field. ER -