PT  - JOURNAL ARTICLE
AU  - MASATSUNE SHIBUTANI
AU  - KIYOSHI MAEDA
AU  - HISASHI NAGAHARA
AU  - HIROSHI OHTANI
AU  - KATSUNOBU SAKURAI
AU  - TAKAHIRO TOYOKAWA
AU  - NAOSHI KUBO
AU  - HIROAKI TANAKA
AU  - KAZUYA MUGURUMA
AU  - MASAICHI OHIRA
AU  - KOSEI HIRAKAWA
TI  - Significance of CEA and CA19-9 Combination as a Prognostic Indicator and for Recurrence Monitoring in Patients with Stage II Colorectal Cancer
DP  - 2014 Jul 01
TA  - Anticancer Research
PG  - 3753--3758
VI  - 34
IP  - 7
4099  - http://ar.iiarjournals.org/content/34/7/3753.short
4100  - http://ar.iiarjournals.org/content/34/7/3753.full
SO  - Anticancer Res2014 Jul 01; 34
AB  - Background: The purpose of this study was to evaluate the significance of the combination of the carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels as a prognostic indicator and for monitoring for recurrence and metastasis after potentially curative surgery for patients with stage II colorectal cancer. Patients and Methods: A total of 238 patients with stage II colorectal cancer who underwent potentially curative surgery were enrolled in the study. A high CEA level was defined as a level exceeding 5 ng/ml and a high CA19-9 level was defined as a level exceeding 37 U/ml. Results: Out of these 238 patients, 92 (38.7%) patients had high CEA levels, 23 (9.7%) patients had high CA19-9 levels and 15 (6.3%) patients had both high CEA and CA19-9 levels. The disease-free and overall survival rates were significantly worse in patients with both a high CEA level and high CA19-9 level. Tumor marker(s) elevated before the operation tended to be elevated again at the time of relapse. Conclusion: The combination of preoperative CEA and CA19-9 levels was useful for predicting the prognosis and for monitoring recurrence and metastasis after potentially curative surgery in patents with stage II colorectal cancer.