PT  - JOURNAL ARTICLE
AU  - DUONG L. LE
AU  - HUYNH CAO
AU  - LI-XI YANG
TI  - Cardiotoxicity of Molecular-targeted Drug Therapy
DP  - 2014 Jul 01
TA  - Anticancer Research
PG  - 3243--3249
VI  - 34
IP  - 7
4099  - http://ar.iiarjournals.org/content/34/7/3243.short
4100  - http://ar.iiarjournals.org/content/34/7/3243.full
SO  - Anticancer Res2014 Jul 01; 34
AB  - Cardiotoxicity is a well-known side-effect described in patients receiving various antineoplastic agents. With the abundance of clinical research and a heavy focus on drug development over the past decade, there has been a major shift in the use of non-specific cytotoxic drugs to molecular-targeted drug therapy. However, as a result, it has become clear that these drugs have numerous adverse effects, both on-target and off-target. Small-molecule tyrosine kinase inhibitors and other molecular-targeted agents, including monoclonal antibodies, have been the primary agents associated with cardiotoxicity. As more molecular-targeted therapies are developed, early recognition and management of drug-related cardiotoxicity will be extremely important in order to reduce morbidity and mortality. Pre-treatment evaluation with a surface electrocardiogram, echocardiography, cardiac history, and comprehensive review of concomitant medications are the current mainstay of treatment. However, much is still unknown about the potential cardiotoxic side-effects of these drug and optimal management. In the present article, we aim to review the cardiovascular implications and related cardiotoxicities associated with molecular target-based chemotherapeutic agents, with special emphasis on hypertension, cardiac dysfunction, and QT prolongation. Their implication, mechanism, and management are discussed where possible.