TY - JOUR T1 - Evaluation of the Contribution of Methylenetetrahydrofolate Reductase Genotypes to Taiwan Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 4109 LP - 4115 VL - 34 IS - 8 AU - CHUNG-YU HUANG AU - WEN-SHIN CHANG AU - HAO-AI SHUI AU - YUNG-HUNG HSIEH AU - CHING-HUI LOH AU - HWEI-CHUNG WANG AU - HONG-XUE JI AU - CHIEH-LUN HSIAO AU - CHIN-MU HSU AU - CHIA-WEN TSAI AU - DA-TIAN BAU Y1 - 2014/08/01 UR - http://ar.iiarjournals.org/content/34/8/4109.abstract N2 - The aim of the present study was to evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and its interaction with early-onset breast cancer risk in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed. In total, 1,232 patients with breast cancer and 1,232 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The MTHFR C677T genotype, but not the A1298C, was differently distributed between cancer and control groups. The T allele of MTHFR C677T was significantly more frequently found in controls than in patients with cancer. In addition, females carrying MTHFR C677T CT or TT genotypes had a higher odds ratio of 1.21 (95% confidence interval=1.03-1.42, p=1.85E-5) for breast cancer, especially before the age of 45.4 years (odds ratio=1.51 and 95% confidence interval=1.20-1.90). Our results indicate that MTHFR C677T T allele was associated with increased risk of breast cancer in Taiwan, especially in cases who were 45.4 old or younger and with earlier menarche age (<12.2 years). ER -