RT Journal Article SR Electronic T1 Radio-chemotherapy with Temozolomide in Elderly Patients with Glioblastoma. A Mono-institutional Experience JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4281 OP 4285 VO 34 IS 8 A1 PASQUALETTI, FRANCESCO A1 FERRAZZA, PATRIZIA A1 COCUZZA, PAOLA A1 FATIGANTE, LUCIA A1 PASQUALETTI, GIUSEPPE A1 FABBRINI, MARIA GRAZIA A1 MONZANI, FABIO YR 2014 UL http://ar.iiarjournals.org/content/34/8/4281.abstract AB Aim: The aim of the present study was to evaluate the toxicity and clinical outcome of radio-chemotherapy with temozolomide in patients with glioblastoma aged more than 65 years. Materials and Methods: The analysis was performed in 20 male and 20 female patients with a mean age at diagnosis of 71.2 (range=65-81) years, with Karnofsky performance status greater than 70 without important comorbidities. Results: Toxicities related to temozolomide and concomitant radiochemotherapy were similar to those reported for younger patients. The median time to progression and median overall survival of the entire cohort, from the date of diagnosis, were 10.6 (range=6.7-14.4) months and 19.3 (range=17.8-20.7) months, respectively. No significant results for overall survival analysis were found for age at diagnosis and cardiovascular risk factors, as covariates, with hazard ratios of 1.00 (95% confidence interval=0.92-1.10) and 0.9 (95% confidence interval=0.43-1.88), respectively. Conclusion: Considering the relative good toxicity profile and the efficacy of treatment, our experience supports the use of radiochemotherapy with temozolomide in older patients with glioblastoma.