RT Journal Article
SR Electronic
T1 High-dose-rate Brachytherapy and Concurrent Chemoradiotherapy Followed by Surgery for Stage Ib-IIb Cervical Cancer: Single Institution Experience
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3861
OP 3866
VO 34
IS 7
A1 FRÖBE, ANA
A1 JONES, GLENN
A1 BOKULIĆ, TOMISLAV
A1 MRČELA, IVA
A1 BUDANEC, MIRJANA
A1 MURGIĆ, JURE
A1 JAKŠIĆ, BLANKA
A1 PRPIĆ, MARIN
A1 BOLANČA, ANTE
A1 KUSIĆ, ZVONKO
YR 2014
UL http://ar.iiarjournals.org/content/34/7/3861.abstract
AB Background: There are still controversies about the benefit of surgery after concurrent radiochemotherapy (CRT) for locally advanced cervical cancer. The aim of this study was to evaluate toxicity, local tumor control and overall survival of surgery after CRT in stage IB-IIB cervical cancer. Patients and Methods: Between 2002 and 2008, 24 patients with stage IB-IIB cervical cancer were treated with external-beam radiotherapy concomitantly with chemotherapy. High-dose rate brachytherapy fractions were given once weekly. Radical hysterectomy was undertaken after a median of 42 days. Results: Overall survival at five years was estimated at 75% (95% confidence interval=52-88%) and sustained thereafter through to 8.9 years. No patient experienced local failure in the surgical bed. Postoperative complications were recorded in two patients. Conclusion: Surgery after CRT in stage IB-IIB cervical cancer is safe and leads to better local control of the disease and overall survival.