TY - JOUR T1 - High-dose-rate Brachytherapy and Concurrent Chemoradiotherapy Followed by Surgery for Stage Ib-IIb Cervical Cancer: Single Institution Experience JF - Anticancer Research JO - Anticancer Res SP - 3861 LP - 3866 VL - 34 IS - 7 AU - ANA FRÖBE AU - GLENN JONES AU - TOMISLAV BOKULIĆ AU - IVA MRČELA AU - MIRJANA BUDANEC AU - JURE MURGIĆ AU - BLANKA JAKŠIĆ AU - MARIN PRPIĆ AU - ANTE BOLANČA AU - ZVONKO KUSIĆ Y1 - 2014/07/01 UR - http://ar.iiarjournals.org/content/34/7/3861.abstract N2 - Background: There are still controversies about the benefit of surgery after concurrent radiochemotherapy (CRT) for locally advanced cervical cancer. The aim of this study was to evaluate toxicity, local tumor control and overall survival of surgery after CRT in stage IB-IIB cervical cancer. Patients and Methods: Between 2002 and 2008, 24 patients with stage IB-IIB cervical cancer were treated with external-beam radiotherapy concomitantly with chemotherapy. High-dose rate brachytherapy fractions were given once weekly. Radical hysterectomy was undertaken after a median of 42 days. Results: Overall survival at five years was estimated at 75% (95% confidence interval=52-88%) and sustained thereafter through to 8.9 years. No patient experienced local failure in the surgical bed. Postoperative complications were recorded in two patients. Conclusion: Surgery after CRT in stage IB-IIB cervical cancer is safe and leads to better local control of the disease and overall survival. ER -