RT Journal Article
SR Electronic
T1 Role of Cytokine Gene Polymorphisms in Gastric Cancer Risk in Chile
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3523
OP 3530
VO 34
IS 7
A1 PATRICIO GONZALEZ-HORMAZABAL
A1 MAHER MUSLEH
A1 MARCO BUSTAMANTE
A1 JUAN STAMBUK
A1 SUSANA ESCANDAR
A1 HECTOR VALLADARES
A1 ENRIQUE LANZARINI
A1 HECTOR CHIONG
A1 JORGE ROJAS
A1 V. GONZALO CASTRO
A1 CRISTIAN RUBIO-REYES
A1 LILIAN JARA
A1 ZOLTAN BERGER
YR 2014
UL http://ar.iiarjournals.org/content/34/7/3523.abstract
AB Aim: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility. Patients and Methods: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1β -IL1B-, IL8, IL17A, IL17F, IL32, tumor necrosis factor-α –TNF-, IL1RN, IL10) in a case–control study of 147 patients with gastric cancer and 172 controls. Results: Single polymorphism analysis revealed an association between the IL10 -592C>A single nucleotide polymorphism and cases with moderately- or well-differentiated tumors [AA vs. GG, odds ratio (OR)=3.01; 95% confidence interval (CI)=1.08-8.50]. We further analyzed gene–gene interactions using a combined attribute network implemented in multifactor dimensionality reduction software. The analysis revealed an interaction between IL8 -251A>T and IL32 rs28372698 SNPs among cases with moderately- or well-differentiated tumors. Homozygosity for both IL8 -251T and IL32 T alleles increases the odds for developing gastric cancer up to 2.63-fold (OR=2.63; 95% CI=1.15-6.03). This association was higher compared to the homozygosity for the IL8-251 T allele alone (OR=1.11; 95% CI=0.51-2.43) or the IL32 T allele alone (OR=1.21; 95% CI=0.54-2.72). Conclusion: These findings suggest that IL10 -592C>A increases the odds for developing gastric cancer. An interaction between IL8 -251A>T and IL32 rs28372698 SNPs is also proposed.