PT  - JOURNAL ARTICLE
AU  - CHRISTOPHER KOBIERZYCKI
AU  - BARTOSZ PULA
AU  - BOZENA WERYNSKA
AU  - ALEKSANDRA PIOTROWSKA
AU  - BEATA MUSZCZYNSKA-BERNHARD
AU  - PIOTR DZIEGIEL
AU  - DARIUSZ RAKUS
TI  - The Lack of Evidence for Correlation of Pyruvate Kinase M2 Expression with Tumor Grade in Non-small Cell Lung Cancer
DP  - 2014 Jul 01
TA  - Anticancer Research
PG  - 3811--3817
VI  - 34
IP  - 7
4099  - http://ar.iiarjournals.org/content/34/7/3811.short
4100  - http://ar.iiarjournals.org/content/34/7/3811.full
SO  - Anticancer Res2014 Jul 01; 34
AB  - Background: Over the last years, evidence has accumulated that an increased expression of pyruvate kinase M2 isozyme (PKM2) is related to neoplastic transformation as well that its plasma concentrations might be a marker of lung cancer progression. Materials and Methods: In the present manuscript an immunohistochemical technique was used to detect the expression of two pyruvate kinase isoforms: PKM1 (muscle isozyme of PK) and PKM2 as well Ki-67 antigen on paraffin sections of 218 cases of non-small cell lung cancer (NSCLC) of different histological types and grades of malignancy. Results: A significant correlation between expressions of both pyruvate kinase isoforms in all NSCLC types was found (r=0.42, p<0.0001). Expression levels of PKM1 and PKM2 were independent of the histological classification of the tumor and patients' clinicopathological data. Conclusions: PKM2 and PKM1 have no value as predictive markers of NSCLC regardless of the histological type and grade of malignancy.