TY - JOUR T1 - Clinical Significance of Tartrate-resistant Acid Phosphatase Type-5 Expression in Human Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 3425 LP - 3429 VL - 34 IS - 7 AU - MIKIO KAWAMURA AU - KOJI TANAKA AU - YUJI TOIYAMA AU - YOSHINAGA OKUGAWA AU - MASATO OKIGAMI AU - HIROMI YASUDA AU - SUSUMU SAIGUSA AU - MASAKI OHI AU - YASUHIRO INOUE AU - KEIICHI UCHIDA AU - YASUHIKO MOHRI AU - MASATO KUSUNOKI Y1 - 2014/07/01 UR - http://ar.iiarjournals.org/content/34/7/3425.abstract N2 - Aim: The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. Materials and Methods: In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and quantitative real-time polymerase chain reaction, respectively. Results: Expression of ACP5 mRNA was significantly higher in cancer tissues than in adjacent normal mucosa. Elevated ACP5 mRNA was associated with lymph node metastasis and peritoneal dissemination. Logistic regression analysis revealed that elevated ACP5 expression was an independent risk factor for peritoneal dissemination and was associated with shorter survival. Immunohistochemical staining of primary carcinomas showed ACP5 to be expressed mainly in the cytoplasm. Conclusion: ACP5 is predictive of peritoneal dissemination in patients with gastric cancer, and might play a crucial role in the establishment of peritoneal dissemination. ER -