RT Journal Article
SR Electronic
T1 Perioperative Venous Thromboembolism in Patients with Gynecological Malignancies: A Lesson from Four Years of Recent Clinical Experience
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3589
OP 3595
VO 34
IS 7
A1 AKIKO MORIMOTO
A1 YUTAKA UEDA
A1 TAKESHI YOKOI
A1 YUKI TOKIZAWA
A1 KIYOSHI YOSHINO
A1 MASAMI FUJITA
A1 TOSHIHIRO KIMURA
A1 EIJI KOBAYASHI
A1 SHINYA MATSUZAKI
A1 TOMOMI EGAWA-TAKATA
A1 KENJIRO SAWADA
A1 TATEKI TSUTSUI
A1 TADASHI KIMURA
YR 2014
UL http://ar.iiarjournals.org/content/34/7/3589.abstract
AB Aim: To analyze clinical characteristics of venous thromboembolisms (VTE) in gynecological malignancies, and to find a cost-effective prophylaxis procedure for post-operative VTE. Patients and Methods: We analyzed clinical characteristics of 751 patients who underwent definitive surgery for gynecologic malignancies, and cost-effectiveness of VTE prophylaxis. Results: VTE was diagnosed preoperatively in 4.5% of ovarian cancer cases, more frequently than any other type (p<0.005). Older age and greater length of operation were independent risk factors for postoperative VTE. To prevent eight VTEs in 738 malignant cases, which occurred during day 2 to 10, $617,783, $726,185, or $994,222 were necessary for continuous VTE prophylaxis, using either unfractionated heparin (UFH), low-molecular weight heparin or fondaparinux, respectively. Conclusion: A strategy which might be cost-effective for post-surgical management of gynecological malignances is use of UFH three times combined with graduated compression stockings and intermittent pneumatic compression, thorough SpO2 monitoring, and perioperative measurements of the circumference of both sides of thighs and calves.