RT Journal Article
SR Electronic
T1 Immunohistochemical Evaluation of CXCL12–CXCR4 Axis and VEGFR3 Expression in Primary Urothelial Cancer and its Recurrence
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3537
OP 3542
VO 34
IS 7
A1 BATSI, OURANIA
A1 GIANNOPOULOU, IOANNA
A1 NESSERIS, IOANNIS
A1 VALAVANIS, CHRISTOS
A1 GAKIOPOULOU, HARIKLIA
A1 PATSOURIS, EFSTRATIOS S.
A1 ARAPANDONI–DADIOTI, PETROULA
A1 LAZARIS, ANDREAS C.
YR 2014
UL http://ar.iiarjournals.org/content/34/7/3537.abstract
AB Aim: The aim of this study was to investigate the expression of CXC chemokine ligand-12 (CXCL12), CXC chemokine receptor 4 CXCR4 and of vascular endothelial growth factor receptor 3 (VEGFR3) in primary urothelial bladder carcinoma and their recurrence in relation to grade and pT status. Materials and Methods: Immunohistochemistry was applied to 67 primary tumor (PC) sections and their recurrenct tumors (RC). Results: The expression of CXCL12 both in PC and in RC was positively associated with tumor grade (p<0.0001 and p<0.0001, respectively) and pT stage (p=0.001 and p=0.007, respectively). The expression of CXCR4 in both PC and RC was also positively related to grade (p=0.001 and p<0.0001, respectively) and pT stage (p=0.008 and p=0.005, respectively). We compared the expression of CXCL12 and CXCR4 in PC related to RC and found that both were more intense in RC than in PC (p<0.0001 and p<0.0001, respectively). In PC and in RC there was no association between the expression of VEGFR3 with tumor grade and pT stage. Conclusion: CXCL12 and CXCR4 expression was related to adverse prognostic markers in urothelial bladder carcinoma through their association with grade and pT stage both in PC and RC. The CXCL12–CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.