TY - JOUR T1 - Long-term Follow-up of Intermediate-risk Non-muscle Invasive Bladder Cancer Sub-classified by Multi-coloured FISH JF - Anticancer Research JO - Anticancer Res SP - 3067 LP - 3071 VL - 34 IS - 6 AU - CHRISTINE MIAN AU - EVI COMPLOJ AU - ELISABETH RESNYAK AU - EMANUELA TRENTI AU - SALVATORE PALERMO AU - MICHELE LODDE AU - ALEXANDER PYCHA AU - ANDREA AMBROSINI-SPALTRO AU - CHRISTOPHER B. DECHET AU - ARMIN PYCHA Y1 - 2014/06/01 UR - http://ar.iiarjournals.org/content/34/6/3067.abstract N2 - Aim: To examine the long-term follow-up of patients with that previously underwent risk stratification based on multicolour FISH testing. Patients and Methods: On 81 patients with intermediate-risk urothelial carcinoma, a multicolour-FISH was performed. Patients were sub-divided into low- and high-risk groups based on chromosomal patterns. Univariate analysis, using Mantel-Cox log-rank test for disease-free, progression-free survival and overall survival, was employed to determine the prognostic significance of FISH analysis. Survival times were calculated according to the Kaplan-Meier product-limit method and multivariate analysis using Cox proportional hazards regression model. Results: The univariate Mantel-Cox log-rank test showed significant differences between the low-risk and the high-risk group for disease-free survival (p=0.005) and overall survival (p=0.038), but not for progression-free survival (p=0.129). Conclusion: Our long-term follow-up data appear to be able to divide tumors into low and high risk groups for recurrence based on molecular/genetic changes observed with FISH. ER -