RT Journal Article
SR Electronic
T1 Cell-Adhesion Molecule Expression and the Proliferation of Malignant Mesothelioma: A Post-Mortem Examination
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3061
OP 3065
VO 34
IS 6
A1 KOZO KURIBAYASHI
A1 HIROSHI HIRANO
A1 KEIJI NAKASHO
A1 HIDEKI OHYAMA
A1 KOJI YAMANEGI
A1 CHIHARU TABATA
A1 KAZUYA FUKUOKA
A1 YOSHIHIRO FUJIMORI
A1 TAKASHI NAKANO
YR 2014
UL http://ar.iiarjournals.org/content/34/6/3061.abstract
AB Aim: In order to determine if metastatic malignant mesothelioma cells are more aggressive than primary malignant mesothelioma cells, an analysis of the expression of the adhesion molecules E-cadherin and β-catenin, concomitant with an assessment of the proliferative activity at primary and metastatic sites, was conducted in post-mortem samples. Materials and Methods: E-cadherin or β-catenin expression was graded according to the percentage of positively-stained tumor cells. The proliferative activity was quantified by the Ki-67 labeling index. Results: Histologically, the majority of metastatic tumors matched the primary tumor. In the epithelioid component of primary tumors, E-cadherin and β-catenin expression ranged from 1+ to 4+. Conclusion: Malignant mesothelioma cells acquire a higher proliferative potential after metastasis, without any significant changes in their histology, although metastasis produces no definite trend on the expression of E-cadherin or β-catenin.