RT Journal Article SR Electronic T1 Multimodal Approach for Cervical Esophageal Carcinoma: Role of Neoadjuvant Chemotherapy JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1989 OP 1992 VO 34 IS 4 A1 GEN SUZUKI A1 HIDEYA YAMAZAKI A1 ETSUYO OGO A1 TOSHI ABE A1 HIDEHIRO ETO A1 KOICHIRO MURAKI A1 CHIKAYUKI HATTORI A1 HIROHITO UMENO A1 TADASHI NAKASHIMA A1 TOSHIAKI TANAKA A1 SATOAKI NAKAMURA A1 KEN YOSHIDA YR 2014 UL http://ar.iiarjournals.org/content/34/4/1989.abstract AB Aim: To examine the outcome of patients with cervical esophageal cancer treated by a multimodal protocol. Patients and Methods: We retrospectively analyzed the outcome and prognostic factors for 20 patients with cervical esophageal cancer who received multimodal treatment at the Kurume University Hospital between 2003 and 2009. One case of stage I, seven of stage II and 12 of stage III disease (2 T1, 3 T2, 4 T3, 11 T4 and 14 N1) were included. Radiotherapy was administered at a median dose of 60 Gy (range=30-70 Gy). The median follow-up time was 32 months for surviving patients (14-94 months). Platinum-based neoadjuvant chemotherapy (NAC) was performed in 14 cases and all received chemoradiotherapy. Results: median survival was 20 months and overall survival rates at 1, 2, and 5-years were 70%, 60% and 30%, respectively. T-Category, length of the primary lesion, N-category, stage, hemoglobin levels and response to induction chemotherapy were statistically significant predisposing factors for overall survival rate. According to NAC response, 10 good responders (complete response or partial response) showed 2-year survival rates of 80% (5 survivors), whereas that for poor responder (stable disease and progressive disease) was 0% (p=0.006), respectively. Response to NAC was the only statistically significant predisposing factor for increased progression-free survival (p=0.03). Severe acute toxicities of grade 3 or more appeared in 5 patients; two grade 5 (esophageal perforations and lung fistula), one grade 4 (bilateral recurrent nerve palsy), and two grade three (pneumonitis and mucositis). Conclusion: Although severe prognosis was identified for cervical esophageal cancer, good response to NAC indicates a good prognosis with organ preservation even for those with T4 tumor.