PT  - JOURNAL ARTICLE
AU  - ENRICO M. PASQUAL
AU  - SERENA BERTOZZI
AU  - STEFANO BACCHETTI
AU  - AMBROGIO P. LONDERO
AU  - STEFANO M. M. BASSO
AU  - DAVIDE A. SANTEUFEMIA
AU  - GIOVANNI LO RE
AU  - FRANCO LUMACHI
TI  - Preoperative Assessment of Peritoneal Carcinomatosis in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy Following Cytoreductive Surgery
DP  - 2014 May 01
TA  - Anticancer Research
PG  - 2363--2368
VI  - 34
IP  - 5
4099  - http://ar.iiarjournals.org/content/34/5/2363.short
4100  - http://ar.iiarjournals.org/content/34/5/2363.full
SO  - Anticancer Res2014 May 01; 34
AB  - The present study evaluates the accuracy of computed tomographic (CT) scan and positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET)/CT for the quantification of peritoneal carcinomatosis (PC) in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Data were retrospectively collected for 58 patients, who were considered for CRS and HIPEC. The predictability, sensitivity, specificity and accuracy values of FDG-PET/CT and CT were tested. Preoperative CT and FDG-PET/CT failed to detect PC in 9% and 17% of cases, respectively, with a sensitivity of 91% and 82%, a specificity of 33% and 67%, an area under the curve (AUC) of 62% and 74% and a negative likelihood ratio of 0.27 (CI.95 0.07-1.09) and 0.27 (CI.95 0.11-0.62), respectively (p=0.469). Both techniques showed a high prevalence of PC extent underestimation (CT 47% and FDG-PET/CT 43% of cases). Small bowel involvement and optimal CRS had a prevalence of 60% and 76%, respectively, and both the CT and FDG-PET/CT imaging techniques were inaccurate at predicting them (AUC 53% and 52% for small bowel involvement, and 63% and 58% for optimal CRS, respectively). In conclusion both CT and FDG-PET/CT had low preoperative staging reliability for PC, and this can strongly influence the ability to implement the correct treatment strategy for patients with PC.