TY - JOUR T1 - Contemporary Review of Large Adrenal Tumors in a Tertiary Referral Center JF - Anticancer Research JO - Anticancer Res SP - 2581 LP - 2588 VL - 34 IS - 5 AU - DIANE MEGE AU - DAVID TAIEB AU - AOIFE LOWERY AU - ANDERSON LOUNDOU AU - CATHERINE DE MICCO AU - FREDERIC CASTINETTI AU - ISABELLE MORANGE AU - JEAN-FRANÇOIS HENRY AU - FREDERIC SEBAG Y1 - 2014/05/01 UR - http://ar.iiarjournals.org/content/34/5/2581.abstract N2 - Background: Large adrenal tumors (LATs, ≥6 cm) are uncommon and associated with malignancy in 25% of cases. Their surgical management remains debatable. The aim of the present report was to evaluate the current incidence, nature and management of LAT. Patients and Methods: We carried out a retrospective review of LATs managed in a tertiary referral center (2002-2011). Results: Eighty-one patients were included (out of a total of 750 with adrenal tumors, 11%). Nine patients had no surgical intervention (11%). Fifty-two LATs were malignant (64%): adrenocortical carcinoma (44%), metastasis (27%) and pheochromocytoma (21%). Patients with malignant tumors exhibited a poorer 5-year overall survival than those with benign tumors (53.4% versus 96.3%, p=0.001). Disease-related mortality was approximately 60%, 29% and 0% for those with metastasis, adrenal carcinoma and malignant pheochromocytoma, respectively. The recurrence rate was the same for the three malignant sub-groups (30%). Conclusion: LATs are rare and more frequently malignant than previously reported. Some are benign and do not require for surgical intervention. Surgical indication and approach should be tailored for each patient. ER -