TY - JOUR T1 - Influence of Thyroid Transcription Factor-1 on Fluorodeoxyglucose Uptake and Prognosis of Non-small Cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 2467 LP - 2475 VL - 34 IS - 5 AU - HEAN OOI AU - CHING-YUAN CHEN AU - YU-CHUN HSIAO AU - WEN-SHENG HUANG AU - BOR-TSUNG HSIEH Y1 - 2014/05/01 UR - http://ar.iiarjournals.org/content/34/5/2467.abstract N2 - Aim: To assess the correlation between thyroid transcription factor-1 (TTF1) protein expression in primary tumors from patients with non-small cell lung cancer (NSCLC) and fluorodeoxyglucose (FDG) uptake, and to determine its effect on survival outcomes. Patients and Methods: We categorized 112 patients with NSCLC according to TTF1 expression (TTF1+: n=59, TTF1−: n=53), and retrospectively determined whether positron-emission topography measurements, including standardized uptake values [mean (SUVm) and maximum (SUVmax)], metabolic tumor volume (MTV), total lesion glycolysis (TLG), and other clinical factors could predict progression-free (PFS) or overall (OS) survival of these patients. Results: The SUVm, SUVmax, MTV, and TLG values were lower in the TTF1+ group; their survival outcomes were also better. The SUVm, SUVmax, and TLG values were good prognostic indicators for OS and PFS in this group. Conclusion: Primary NSCLC tumors expressing TTF1 had lower FDG uptake than those that did not and this was a good prognostic indicator. ER -