RT Journal Article
SR Electronic
T1 The Clinical Impact of the Lymph Node Ratio as a Prognostic Factor after Resection of Pancreatic Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2389
OP 2394
VO 34
IS 5
A1 YUSUKE YAMAMOTO
A1 HISASHI IKOMA
A1 RYO MORIMURA
A1 HIROTAKA KONISHI
A1 YASUTOSHI MURAYAMA
A1 SHUHEI KOMATSU
A1 ATSUSHI SHIOZAKI
A1 YOSHIAKI KURIU
A1 TAKESHI KUBOTA
A1 MASAYOSHI NAKANISHI
A1 DAISUKE ICHIKAWA
A1 HITOSHI FUJIWARA
A1 KAZUMA OKAMOTO
A1 CHOUHEI SAKAKURA
A1 TOSHIYA OCHIAI
A1 EIGO OTSUJI
YR 2014
UL http://ar.iiarjournals.org/content/34/5/2389.abstract
AB Background: The prognostic value of lymph node (LN) status in patients who underwent resection for pancreatic cancer (PC) was examined in the present study. Patients and Methods: Fifty-six patients who underwent macroscopic curative resection for PC were analyzed. Twelve factors, including the number of LN metastases, LN ratio, and N category according to the Japanese Pancreatic Society classification, were analyzed using univariate and multivariate analysis. Results: The optimal cut-off value was 0.2 for the LN ratio. Positive surgical margins (p=0.022) and LN ratio ≥0.2 (p=0.017) were identified as independent prognostic factors. Among the 33 patients with regional LN metastasis, patients with LN ratio ≥0.2 had significantly worse prognosis than those with LN ratio <0.2 (median survival time 14 vs. 26 months, p=0.048), however, the differences in survival between those with N1 and those with N2 by Japanese Pancreatic Society classification were not statistically significant (p=0.85). Conclusion: The LN ratio might be more useful than other parameters as a predictor for survival after resection of PC.