PT  - JOURNAL ARTICLE
AU  - VETVICKA, VACLAV
AU  - VETVICKOVA, JANA
TI  - Natural Immunomodulators and their Stimulation of Immune Reaction: True or False?
DP  - 2014 May 01
TA  - Anticancer Research
PG  - 2275--2282
VI  - 34
IP  - 5
4099  - http://ar.iiarjournals.org/content/34/5/2275.short
4100  - http://ar.iiarjournals.org/content/34/5/2275.full
SO  - Anticancer Res2014 May 01; 34
AB  - Natural immunomodulators are getting more and more popular. The popularity, however, often brings over-optimistic claims and mediocre effects. The purpose of the present study was to directly compare eleven most commonly used immunomodulators. Through testing both cellular and humoral branches of immune reactions, we found that most of the immunomodulators tested have limited, if any, effects, with glucan being consistently the most active molecule strongly stimulating every reaction evaluated. These data were also confirmed using a Lewis lung cancer model, where only glucan and resveratrol lowered the number of metastases.