RT Journal Article SR Electronic T1 A Novel Tetramethylnaphthalene Derivative Selectively Inhibits Adult T-Cell Leukemia (ATL) Cells In Vitro JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1771 OP 1778 VO 34 IS 4 A1 MASAAKI TOYAMA A1 HIROSHI AOYAMA A1 RISA MUKAI A1 MASAHARU NAKAMURA A1 KOJI YOSHIMURA A1 MIKA OKAMOTO A1 TAKAYUKI OHSHIMA A1 YUICHI HASHIMOTO A1 MASANORI BABA YR 2014 UL http://ar.iiarjournals.org/content/34/4/1771.abstract AB Adult T-cell leukemia (ATL) is caused by infection with human T-cell leukemia virus type-1 (HTLV-1). The tetrahydrotetramethylnaphthalene derivative TMNAA has recently been identified as a selective inhibitor of HTLV-1-infected T-cell lines and adult T-cell leukemia (ATL) cells but not of uninfected T-cell lines and peripheral blood mononuclear cells (PBMCs). In the present study, more than 100 derivatives of TMNAA were synthesized and examined for their inhibitory effects on the proliferation of various T-cell lines and PBMCs. Among the compounds, MN417 is a more potent inhibitor of ATL cells than TMNAA. This compound is a novel phenanthridinone derivative with the tetrahydrotetramethylnaphthalene structure. Interestingly, PN-H and MN314-B, which are also phenanthridinone derivatives but do not have the tetrahydrotetramethylnaphthalene structure, could not distinguish between HTLV-1-infected and uninfected T-cell lines in terms of their anti-proliferative activity. These results suggest that the tetrahydrotetramethylnaphthalene structure is required for the selective inhibition of HTLV-1-infected cells.