RT Journal Article
SR Electronic
T1 Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1163
OP 1166
VO 34
IS 3
A1 MOHR, SHARIF B.
A1 GORHAM, EDWARD D.
A1 KIM, JUNE
A1 HOFFLICH, HEATHER
A1 GARLAND, CEDRIC F.
YR 2014
UL http://ar.iiarjournals.org/content/34/3/1163.abstract
AB Background/Aim: To determine whether higher serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is associated with longer survival of patients with breast cancer. Materials and Methods: A meta-analysis was performed of five studies of the relationship between 25(OH)D and mortality from breast cancer. A pooled hazard ratio was calculated using a random-effects model. The Der Simonian-Laird test was used to assess homogeneity. Results: Higher serum concentrations of 25(OH)D were associated with lower case-fatality rates after diagnosis of breast cancer. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest. Conclusion: High serum 25(OH)D was associated with lower mortality from breast cancer. Serum 25(OH)D in all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. Clinical or field studies should be initiated to confirm that this association was not due to reverse causation.