RT Journal Article
SR Electronic
T1 Anaplastic Pelvic Carcinoma Secondary to Low-grade Endometrial Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 239
OP 242
VO 34
IS 1
A1 WATROWSKI, RAFAL
A1 MÖCKEL, JOCHEN
A1 VENZKE, THORSTEN
A1 JÄGER, CHRISTOPH
A1 BAUKNECHT, THOMAS
YR 2014
UL http://ar.iiarjournals.org/content/34/1/239.abstract
AB Background: Low-grade endometrial carcinoma has an excellent prognosis. The risk of secondary cancer after endometrial carcinoma is moderately increased and is mostly related to the field of postoperative radiation (small intestine, colon, vagina, and urinary bladder). Anaplastic (undifferentiated) pelvic carcinoma (APC) is rare and probably under-reported. To date, only one publication has reported six cases of APC that were secondary to low-grade endometrial carcinoma. Case Report: We have analyzed the fulminant course of APC–preceded by paraneoplastic arthritis–four months after hysterectomy and adnexectomy for low-grade endometrial carcinoma (endometrioid type, moderately differentiated, tumor diameter: 2 cm, infiltration depth 3 of 15 mm). The 73-year-old patient died five weeks after the diagnosis of the second malignancy. Conclusion: The prognosis of APC is poor and the limitations of the therapy result from aggressive tumor biology and rapid deterioration of the patients' general condition. Rheumatological symptoms can precede cancer diagnosis. Immunohistochemistry facilitates the differentiation between primary and secondary carcinoma.