TY - JOUR T1 - Oxoglaucine-Lanthanide Complexes: Synthesis, Crystal Structure and Cytotoxicity JF - Anticancer Research JO - Anticancer Res SP - 531 LP - 536 VL - 34 IS - 1 AU - YAN-CHENG LIU AU - ZHEN-FENG CHEN AU - YAN-FANG SHI AU - KE-BIN HUANG AU - BO GENG AU - HONG LIANG Y1 - 2014/01/01 UR - http://ar.iiarjournals.org/content/34/1/531.abstract N2 - Aim: To evaluate the in vitro cytotoxicity of oxoglaucine (OG) complexes: [Sm(OG)2(NO3)3]•H2O (1), [Eu(OG)2(NO3)3]•1.5CH3OH (2) and [Er(OG)2(NO3)3]•H2O (3) through comparison to oxoglaucine and lanthanide salts. Materials and Methods: The reactions of OG with corresponding lanthanide salts gave rise to complexes 1-3. The crystal structures of complexes 1-3 were determined by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of oxoglaucine and complexes 1-3 against five human cancer cell lines were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium Bromide (MTT) method. Results: Complexes 1-3 have similar mononuclear structures. The 50% inhibitory concentration (IC50) of complex 1 against SGC7901 cells was 32.1 μM; that of complex 2 against MCF-7 cells was 3.2 μM; those of complex 3 on HeLa and MCF-7 cells were 8.3 and 1.4 μM, respectively. Conclusion: The three OG-lanthanide complexes exhibited significantly enhanced cytotoxicity vs. OG and corresponding lanthanide salts. ER -