PT  - JOURNAL ARTICLE
AU  - GOI, TAKANORI
AU  - NAKAZAWA, TOSHIYUKI
AU  - HIRONO, YASUO
AU  - YAMAGUCHI, AKIO
TI  - Prokineticin 1 Expression in Gastrointestinal Tumors
DP  - 2013 Dec 01
TA  - Anticancer Research
PG  - 5311--5315
VI  - 33
IP  - 12
4099  - http://ar.iiarjournals.org/content/33/12/5311.short
4100  - http://ar.iiarjournals.org/content/33/12/5311.full
SO  - Anticancer Res2013 Dec 01; 33
AB  - Aim: We studied prokineticin 1 (PROK1) expression in human gastrointestinal carcinomas by immunohistochemistry. Materials and Methods: PROK1 expression was examined in human gastrointestinal cancer cell lines and primary gastrointestinal lesions. In addition the relationship between the number of blood vessels and PROK1 expression in these primary lesions was examined. Results: PROK1 expression was observed in gastrointestinal cancer cell lines. PROK1 expression was not observed in healthy gastrointestinal mucosa, but was observed in the primary lesions in 23 out of 98 (31.6%) patients with colorectal cancer, 19 out of 55 (34.5%) patients with gastric cancer, and 5 of 10 (50%) patients with cancer of the small intestine. PROK1 expression was observed in many patients with advanced gastrointestinal cancer. The number of blood vessels in PROK1-positive primary gastrointestinal lesions was higher than that in PROK1-negative primary lesions. Conclusion: PROK1 expression might be related to the extent of malignancy in gastrointestinal cancer.