TY - JOUR T1 - Association of X-ray Repair Cross-complementing-6 Genotypes with Childhood Leukemia JF - Anticancer Research JO - Anticancer Res SP - 5395 LP - 5399 VL - 33 IS - 12 AU - JEN-SHENG PEI AU - YI-MIN LEE AU - HSUEH-HSIA LO AU - YUAN-NIAN HSU AU - SONG-SHEI LIN AU - DA-TIAN BAU Y1 - 2013/12/01 UR - http://ar.iiarjournals.org/content/33/12/5395.abstract N2 - Background: The Non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs), and has been found to be involved in the carcinogenesis of many types of cancers including oral, prostate, breast and bladder cancer. However, the contribution of XRCC6 to childhood leukemia has yet to be studied. In the present study, we investigated the association of XRCC6 genotypes with the risk of childhood leukemia. Materials and Methods: Two hundred and sixty-six patients with childhood leukemia and an equal number of age-matched healthy controls recruited in Central Taiwan, were genotyped investigating these polymorphisms' association with childhood leukemia. Results: As for XRCC6 promoter T-991C, patients carrying the TC genotype had a significantly increased risk of childhood leukemia compared with the TT wild-type genotype [odds ratio (OR)=2.30, 95% confidence interval (CI)=1.38-3.84, p=0.0047]. Meanwhile, the genotypes of XRCC6 promoter C-57G, A-31G and intron3 were not statistically associated with childhood leukemia risk. Conclusion: Our findings suggest that the XRCC6 genotype could serve as a predictor of childhood leukemia risk and XRCC6 could serve as a target for personalized medicine and therapy. ER -