RT Journal Article SR Electronic T1 Associations of Cyclooxygenase 2 Polymorphic Genotypes with Bladder Cancer Risk in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5401 OP 5405 VO 33 IS 12 A1 WEN-SHIN CHANG A1 CHIA-WEN TSAI A1 HONG-XUE JI A1 HSI-CHIN WU A1 YI-TING CHANG A1 CHI-SHUN LIEN A1 WEN-LING LIAO A1 WU-CHUNG SHEN A1 CHANG-HAI TSAI A1 DA-TIAN BAU YR 2013 UL http://ar.iiarjournals.org/content/33/12/5401.abstract AB Aim: Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in southwestern Taiwan. However, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of cyclooxygenase 2 (Cox-2) polymorphic genotypes with Taiwan bladder cancer patients. Materials and Methods: Six polymorphic variants of Cox-2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same amount of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method. Results: Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs20417) genotypes were positively associated with bladder cancer risk (p=0.0102). Individuals with the Cox-2 -765GC genotypes were associated with higher prostate cancer risk than those with -765GG. Conclusion: Our findings provide evidence that the C allele of Cox-2 promoter G-765C may be associated with the overexpression of COX-2 during bladder cancer development and may be a useful marker for the early detection of bladder cancer.