TY - JOUR T1 - Associations of <em>Cyclooxygenase 2</em> Polymorphic Genotypes with Bladder Cancer Risk in Taiwan JF - Anticancer Research JO - Anticancer Res SP - 5401 LP - 5405 VL - 33 IS - 12 AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - HONG-XUE JI AU - HSI-CHIN WU AU - YI-TING CHANG AU - CHI-SHUN LIEN AU - WEN-LING LIAO AU - WU-CHUNG SHEN AU - CHANG-HAI TSAI AU - DA-TIAN BAU Y1 - 2013/12/01 UR - http://ar.iiarjournals.org/content/33/12/5401.abstract N2 - Aim: Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in southwestern Taiwan. However, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of cyclooxygenase 2 (Cox-2) polymorphic genotypes with Taiwan bladder cancer patients. Materials and Methods: Six polymorphic variants of Cox-2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same amount of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method. Results: Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs20417) genotypes were positively associated with bladder cancer risk (p=0.0102). Individuals with the Cox-2 -765GC genotypes were associated with higher prostate cancer risk than those with -765GG. Conclusion: Our findings provide evidence that the C allele of Cox-2 promoter G-765C may be associated with the overexpression of COX-2 during bladder cancer development and may be a useful marker for the early detection of bladder cancer. ER -