TY - JOUR T1 - Radiotherapy for Early-stage Primary Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma JF - Anticancer Research JO - Anticancer Res SP - 5575 LP - 5578 VL - 33 IS - 12 AU - SAIJI OHGA AU - KATSUMASA NAKAMURA AU - YOSHIYUKI SHIOYAMA AU - TOMONARI SASAKI AU - TADAMASA YOSHITAKE AU - KAZUSHIGE ATSUMI AU - KOTARO TERASHIMA AU - KAORI ASAI AU - KEIJI MATSUMOTO AU - HIROSHI YOSHIKAWA AU - YO-ICHI KAWANO AU - HIROSHI HONDA Y1 - 2013/12/01 UR - http://ar.iiarjournals.org/content/33/12/5575.abstract N2 - Background: Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. Patients and Methods: From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years. Results: All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy. Conclusion: Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors. ER -