TY - JOUR T1 - Comparison of Minichromosome Maintenance Proteins (MCM-3, MCM-7) and Metallothioneins (MT-I/II, MT-III) Expression in Relation to Clinicopathological Data in Ovarian Cancer JF - Anticancer Research JO - Anticancer Res SP - 5375 LP - 5383 VL - 33 IS - 12 AU - CHRISTOPHER KOBIERZYCKI AU - BARTOSZ PULA AU - MATEUSZ SKIBA AU - KAROLINA JABLONSKA AU - KRZYSZTOF LATKOWSKI AU - MACIEJ ZABEL AU - EWA NOWAK-MARKWITZ AU - MAREK SPACZYNSKI AU - WITOLD KEDZIA AU - MARZENA PODHORSKA-OKOLOW AU - PIOTR DZIEGIEL Y1 - 2013/12/01 UR - http://ar.iiarjournals.org/content/33/12/5375.abstract N2 - Background: Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors. Materials and Methods: The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type. Results: Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p<0.0001). The Kruskal–Wallis test showed an association of increased expression of MCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247). Conclusion: Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered. ER -