TY - JOUR T1 - Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors JF - Anticancer Research JO - Anticancer Res SP - 4767 LP - 4770 VL - 33 IS - 11 AU - HANS-CHRISTIAN POMMERGAARD AU - JAKOB BURCHARTH AU - J. ROSENBERG AU - HANS RASKOV Y1 - 2013/11/01 UR - http://ar.iiarjournals.org/content/33/11/4767.abstract N2 - Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs. ER -