RT Journal Article
SR Electronic
T1 Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4767
OP 4770
VO 33
IS 11
A1 HANS-CHRISTIAN POMMERGAARD
A1 JAKOB BURCHARTH
A1 J. ROSENBERG
A1 HANS RASKOV
YR 2013
UL http://ar.iiarjournals.org/content/33/11/4767.abstract
AB Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs.