TY - JOUR T1 - Ethnic Variation in Toxicity and Outcome of Adjuvant Chemoradiation for Gastric Cancer in Israel JF - Anticancer Research JO - Anticancer Res SP - 5151 LP - 5157 VL - 33 IS - 11 AU - RONEN M. BRENNER AU - SHAYE KIVITY AU - YULIA KUNDEL AU - OFER PURIM AU - NIR PELED AU - EFRAIM IDELEVICH AU - KONSTANTIN LAVRENKOV AU - SVETLANA KOVEL AU - EYAL FENIG AU - AARON SULKES AU - BARUCH BRENNER Y1 - 2013/11/01 UR - http://ar.iiarjournals.org/content/33/11/5151.abstract N2 - Background: Data on differences in toxicity and efficacy of chemotherapy and radiotherapy among different ethnic groups is limited. We evaluated differences in toxicity, tolerability and clinical outcome of Ashkenazi and non-Ashkenazi Jews receiving postoperative chemoradiation for locally advanced gastric cancer (LAGC). Patients and Methods: Between 6/2000-12/2007, 84 Ashkenazi patients and 60 non-Ashkenazi patients underwent chemoradiation following resection of LAGC (INT-116 trial). Results: Patients' and tumor characteristics were comparable. Ashkenazi patients experienced significantly higher rates of fatigue, anorexia, and grade 3-4 dysphagia, as well as a trend for a higher rate of diarrhea. The incidence of other toxicities, dose adjustments of chemotherapy and radiotherapy and patient prognosis did not differ. Conclusion: This study shows higher rates of various toxicities among Ashkenazi patients receiving postoperative chemoradiation for LAGC compared to non-Ashkenazi patients. To our knowledge, this is the first study comparing treatment toxicity, tolerability and outcome between these two groups. ER -