PT  - JOURNAL ARTICLE
AU  - RONEN M. BRENNER
AU  - SHAYE KIVITY
AU  - YULIA KUNDEL
AU  - OFER PURIM
AU  - NIR PELED
AU  - EFRAIM IDELEVICH
AU  - KONSTANTIN LAVRENKOV
AU  - SVETLANA KOVEL
AU  - EYAL FENIG
AU  - AARON SULKES
AU  - BARUCH BRENNER
TI  - Ethnic Variation in Toxicity and Outcome of Adjuvant Chemoradiation for Gastric Cancer in Israel
DP  - 2013 Nov 01
TA  - Anticancer Research
PG  - 5151--5157
VI  - 33
IP  - 11
4099  - http://ar.iiarjournals.org/content/33/11/5151.short
4100  - http://ar.iiarjournals.org/content/33/11/5151.full
SO  - Anticancer Res2013 Nov 01; 33
AB  - Background: Data on differences in toxicity and efficacy of chemotherapy and radiotherapy among different ethnic groups is limited. We evaluated differences in toxicity, tolerability and clinical outcome of Ashkenazi and non-Ashkenazi Jews receiving postoperative chemoradiation for locally advanced gastric cancer (LAGC). Patients and Methods: Between 6/2000-12/2007, 84 Ashkenazi patients and 60 non-Ashkenazi patients underwent chemoradiation following resection of LAGC (INT-116 trial). Results: Patients' and tumor characteristics were comparable. Ashkenazi patients experienced significantly higher rates of fatigue, anorexia, and grade 3-4 dysphagia, as well as a trend for a higher rate of diarrhea. The incidence of other toxicities, dose adjustments of chemotherapy and radiotherapy and patient prognosis did not differ. Conclusion: This study shows higher rates of various toxicities among Ashkenazi patients receiving postoperative chemoradiation for LAGC compared to non-Ashkenazi patients. To our knowledge, this is the first study comparing treatment toxicity, tolerability and outcome between these two groups.