TY - JOUR T1 - Improved Survival of Baby Boomer Women with Early-stage Uterine Cancer: A Surveillance, Epidemiology and End Results (SEER) Study JF - Anticancer Research JO - Anticancer Res SP - 4983 LP - 4987 VL - 33 IS - 11 AU - MOHAMED A. ELSHAIKH AU - JULIE RUTERBUSCH AU - MICHELE L. COTE AU - RICHARD CATTANEO II AU - ADNAN R. MUNKARAH Y1 - 2013/11/01 UR - http://ar.iiarjournals.org/content/33/11/4983.abstract N2 - Aim: To study the prognostic impact of baby boomer (BB) generation on survival end-points of patients with early-stage endometrial carcinoma (EC). Patients and Methods: Data were obtained from the SEER registry between 1988–2009. Inclusion criteria included women who underwent hysterectomy for stage I-II EC. Patients were divided into two birth cohorts: BB (women born between 1946 and 1964) and pre-boomers (PB) (born between 1926 and 1945). Results: A total of 30,956 patients were analyzed. Considering that women in the PB group were older than those of the BB generation, the statistical analysis was limited to women 50-59 years of age at the time of diagnosis (n=11,473). Baby boomers had a significantly higher percentage of endometrioid histology (p<0.0001), higher percentage of African American women (p<0.0001), lower tumor grade (p<0.0001), higher number of dissected lymph nodes (LN) (p<0.0001), and less utilization of adjuvant radiation therapy (p=0.0003). Overall survival was improved in women in the BB generation compared to the PB generation (p=0.0003) with a trend for improved uterine cancer-specific survival (p=0.0752). On multivariate analysis, birth cohort (BB vs. PB) was not a significant predictor of survival end-points. Factors predictive of survival included: tumor grade, FIGO stage, African-American race, and increased number of dissected LN. Conclusion: Our study suggests that the survival of BB women between 50-60 years of age is better compared to women in the PB generation. As more BB patients are diagnosed with EC, further research is warranted. ER -