RT Journal Article SR Electronic T1 Platinum-based Combination Chemotherapy vs. Weekly Cisplatin During Adjuvant CCRT in Early Cervical Cancer with Pelvic LN Metastasis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4675 OP 4681 VO 33 IS 10 A1 YOO-YOUNG LEE A1 WON PARK A1 SEUNG JAE HUH A1 AERA YOON A1 JIN-YOUNG PARK A1 CHEL HUN CHOI A1 TAE-JOONG KIM A1 JEONG-WON LEE A1 BYOUNG-GIE KIM A1 DUK-SOO BAE YR 2013 UL http://ar.iiarjournals.org/content/33/10/4675.abstract AB Aim: Adjuvant concurrent chemoradiation (CCRT) should be considered in surgically-treated patients with early-stage cervical cancer (ECC) who exhibit pelvic lymph node (LN) metastasis. Platinum-based chemotherapy is usually recommended during adjuvant CCRT, however, it is unclear which regimen has better prognostic outcomes. Patients and Methods: We reviewed the electronic medical records to find patients with primary ECC (FIGO stages IB-IIA) who underwent type III radical hysterectomy and adjuvant CCRT due to pelvic LN metastasis at the Samsung Medical Center, Sungkyunkwan University School of Medicine in Seoul, Korea, from November 1997 to September 2007. Results: Among 75 patients, 34 received weekly cisplatin. Combination chemotherapy was performed without consolidation in 21 patients and with consolidation in 20 patients. The mean follow-up period was 59.0 months and the five-year survival rate was 84.4%. In multivariate analysis, combination chemotherapy with and without consolidation was associated with improved disease-free survival [hazard ratio (HR)=0.23, 95% confidence interval (CI)=0.06-0.88, p=0.032, and HR=0.29, 95% CI=0.09-0.91, p=0.034, respectively]; combination chemotherapy with consolidation significantly improved overall survival (HR=0.11, 95% CI=0.02-0.87, p=0.037) when compared to weekly cisplatin. Conclusion: We found that platinum-based combination chemotherapy during adjuvant CCRT after surgery promoted better survival than a weekly cisplatin regimen in ECC patients with pelvic LN metastasis.