TY - JOUR T1 - C-Reactive Protein as Predictor of Recurrence in Patients with Rectal Cancer Undergoing Chemoradiotherapy Followed by Surgery JF - Anticancer Research JO - Anticancer Res SP - 5065 LP - 5074 VL - 33 IS - 11 AU - YUJI TOIYAMA AU - YASUHIRO INOUE AU - SUSUMU SAIGUSA AU - MIKIO KAWAMURA AU - AYA KAWAMOTO AU - YOSHINAGA OKUGAWA AU - JYUNICHIRO HIRO AU - KOJI TANAKA AU - YASUHIKO MOHRI AU - MASATO KUSUNOKI Y1 - 2013/11/01 UR - http://ar.iiarjournals.org/content/33/11/5065.abstract N2 - Background: The clinical significance of the systemic inflammatory response (SIR) in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy (CRT), to the best of our knowledge, has not been thus far investigated. Patients and Methods: The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and C-Reactive protein (CRP) levels for 84 patients with rectal cancer undergoing CRT were available as indicators of SIR status. The impact of SIR status on the prognosis of these patients was assessed. Results: Elevated NLR, CRP, carcinoembryonic antigen (CEA) and pathological TNM stage III [ypN(+)] were identified as significant prognostic factors for poor overall survival (OS), with CRP and ypN(+) being validated as independent predictors of OS. Elevated CRP and CEA levels were significant predictive factors for poor disease-free survival (DFS), and an elevated CRP level was identified as the only independent predictive factor for DFS. In addition, an elevated CRP level predicted for poorer OS and DFS in patients with pathological TNM stage I-II [ypN(−)]. Conclusion: CRP is a promising predictor of recurrence and prognosis in patients with rectal cancer treated by CRT. ER -