RT Journal Article SR Electronic T1 Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4373 OP 4380 VO 33 IS 10 A1 SCOTT, KATHERINE ANN A1 SHAH, SINI A1 DALGLEISH, ANGUS GEORGE A1 LIU, WAI MAN YR 2013 UL http://ar.iiarjournals.org/content/33/10/4373.abstract AB Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.