PT  - JOURNAL ARTICLE
AU  - SCOTT, KATHERINE ANN
AU  - SHAH, SINI
AU  - DALGLEISH, ANGUS GEORGE
AU  - LIU, WAI MAN
TI  - Enhancing the Activity of Cannabidiol and Other Cannabinoids <em>In Vitro</em> Through Modifications to Drug Combinations and Treatment Schedules
DP  - 2013 Oct 01
TA  - Anticancer Research
PG  - 4373--4380
VI  - 33
IP  - 10
4099  - http://ar.iiarjournals.org/content/33/10/4373.short
4100  - http://ar.iiarjournals.org/content/33/10/4373.full
SO  - Anticancer Res2013 Oct 01; 33
AB  - Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.