RT Journal Article
SR Electronic
T1 Survival in Patients with Metastatic Spinal Cord Compression from Prostate Cancer Is Associated with the Number of Extra-spinal Organs Involved
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4505
OP 4507
VO 33
IS 10
A1 AXEL WEBER
A1 TOBIAS BARTSCHT
A1 JOHANN H. KARSTENS
A1 STEVEN E. SCHILD
A1 DIRK RADES
YR 2013
UL http://ar.iiarjournals.org/content/33/10/4505.abstract
AB Background/Aim: To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer. Patients and Methods: In 95 patients irradiated with 10×3 Gy for MSCC from prostate cancer, seven factors were investigated: Age, performance score, number of involved vertebrae, interval from prostate cancer diagnosis to MSCC, pre-radiotherapy ambulatory status, time to motor deficits development, number of involved extra-spinal organs. Results: Six-month survival rates for 0, 1 and ≥2 involved extra-spinal organs, were 81, 53 and 33%, respectively (p<0.001). On multivariate analysis, the number of involved extra-spinal organs maintained significance (risk ratio 1.88, p=0.023). Better performance score (p<0.001), longer interval from prostate cancer diagnosis to radiotherapy of MSCC (p<0.001), and being ambulatory prior to radiotherapy (p=0.001) were also positively associated with survival. Conclusion: The number of extra-spinal organs involved by metastases predicts survival in patients with MSCC from prostate cancer.