%0 Journal Article %A ALESSIO G. MORGANTI %A MARIANGELA MASSACCESI %A LUCIANA CARAVATTA %A GABRIELLA MACCHIA %A VINCENZO PICARDI %A FRANCESCO DEODATO %A EDY IPPOLITO %A SAMANTHA MIGNOGNA %A MARICA FERRO %A SAVINO CILLA %A GIAN CARLO MATTIUCCI %A VINCENZO VALENTINI %T Radiotherapy and Concurrent Metronomic Chemotherapy in Hormone-refractory Prostate Carcinoma: A Phase I Study %D 2013 %J Anticancer Research %P 4585-4589 %V 33 %N 10 %X Aim: To determine the maximum tolerated dose of hypofractionated radiotherapy (HFRT) plus concurrent metronomic chemotherapy in patients with hormone-refractory prostate cancer (HRPC). Patients and Methods: A Phase I clinical trial was performed with cohorts of three to six patients per group. Eligible patients had HRPC without distant metastases. The radiotherapy dose was escalated in a stepwise fashion as follows: 60, 65, and 70 Gy at levels 1, 2, and 3, respectively (25 fractions: levels 1-2, and 26 fractions: level 3). Results: Nine patients were enrolled. The radiotherapy dose was escalated from 60 to 70 Gy without any dose-limiting toxicity. The most common grade 1/2 toxicities were hematuria, dysuria, diarrhea and rectal-perirectal pain. The overall objective response rate was 9/9 (100%) (95% CI=66.4%-100%). The median time-to-progression was 19 months. Conclusion: In the challenging setting of HRPC, HFRT up to 70 Gy with concurrent metronomic chemotherapy was well-tolerated and yielded encouraging disease control. %U https://ar.iiarjournals.org/content/anticanres/33/10/4585.full.pdf