TY - JOUR T1 - APO010, A Synthetic Hexameric CD95 Ligand, Induces Death of Human Glioblastoma Stem-like Cells JF - Anticancer Research JO - Anticancer Res SP - 3563 LP - 3571 VL - 33 IS - 9 AU - GÜNTER EISELE AU - FABIAN WOLPERT AU - GUILLAUME DECREY AU - MICHAEL WELLER Y1 - 2013/09/01 UR - http://ar.iiarjournals.org/content/33/9/3563.abstract N2 - The treatment of glioblastoma remains a major challenge in the field of neuro-oncology. There is emerging evidence that glioblastomas consist of heterogeneous cell populations with a small subset of cells with stem cell-like properties which might be resistant to conventional therapy and are thus crucial for tumor recurrence. These glioma-initiating cells (GICs) are therefore an attractive therapeutic target. Death receptor activation is one promising approach of cancer therapy. The synthetic hexameric cluster of differentiation 95 (CD95) agonist APO010 exhibits strong antiglioma activity towards human glioma cell lines, as well as in cell cultures of primary glioblastoma. Here, we investigated the ability of APO010 to induce cell death in a panel of previously well-defined GIC lines. The GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent. Temozolomide enhanced sensitivity of GICs to APO010. APO010 warrants being further evaluated as a tool to target GICs. ER -