RT Journal Article
SR Electronic
T1 Post-operative Lymphocyte Count May Predict the Outcome of Radical Resection for Gallbladder Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3439
OP 3444
VO 33
IS 8
A1 RYOTA IWASE
A1 HIROAKI SHIBA
A1 KOICHIRO HARUKI
A1 YUKI FUJIWARA
A1 KENEI FURUKAWA
A1 YASURO FUTAGAWA
A1 SHIGEKI WAKIYAMA
A1 TAKEYUKI MISAWA
A1 KATSUHIKO YANAGA
YR 2013
UL http://ar.iiarjournals.org/content/33/8/3439.abstract
AB Background: Gallbladder carcinoma (GBC) is a cancer of the digestive tract with poor prognosis, for which surgical resection is the only potentially curative therapy. The prognostic value of postoperative peripheral blood leukocyte subset count in patients with cancer has not been fully investigated. Therefore, we retrospectively investigated the relation-ship between postoperative peripheral blood lymphocyte count and disease-free as well as overall survival after radical resection of GBC. Patients and Methods: The study subjects were 34 patients who underwent radical resection for GBC between January 2005 and April 2010. We retrospectively investigated the relation-ship between clinicopathological variables, including postoperative peripheral blood lymphocyte count, and disease-free as well as overall survival. Results: In univariate analysis, disease-free survival was worse in patients with intraoperative blood transfusion (p=0.0285), tumor node metastasis (TNM) stage ≥II (p<0.0001), and lymphocyte count of less than 1,000/μl (p=0.0002). Overall survival was worse in patients with TNM stage ≥II (p=0.0002) and lymphocyte count of less than 1,000/μl (p=0.0151). In multivariate analysis, TNM stage ≥II (p<0.0089) and peripheral blood lymphocyte count of less than 1,000/μl (p=0.0365) were independent predictors of poor disease-free survival. For overall survival, TNM stage ≥II (p=0.0230) was the only independent predictor. Moreover, lymphocyte counts of less than 1,000/μl correlated significantly with TNM stage ≥II, duration of operation, greater blood loss, and presence of intraoperative blood transfusion. Conclusion: Postoperative peripheral blood lymphocyte count correlates with outcome of patients with GBC treated by radical resection.