PT  - JOURNAL ARTICLE
AU  - CELINA SU-PING ANG
AU  - MARK YIPIN SUN
AU  - DAVID FIDEL HUITZIL-MELENDEZ
AU  - JOANNE FU-LOU CHOU
AU  - MARINELA CAPANU
AU  - WILLIAM JARNAGIN
AU  - YUMAN FONG
AU  - RONALD PAUL DEMATTEO
AU  - MICHAEL D'ANGELICA
AU  - PETER ALLEN
AU  - CHIN-TUNG CHEN
AU  - EILEEN MARY O'REILLY
AU  - MARTIN ROSS WEISER
AU  - GHASSAN KHALED ABOU-ALFA
TI  - <em>c-MET</em> and <em>HGF</em> mRNA Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Survival
DP  - 2013 Aug 01
TA  - Anticancer Research
PG  - 3241--3245
VI  - 33
IP  - 8
4099  - http://ar.iiarjournals.org/content/33/8/3241.short
4100  - http://ar.iiarjournals.org/content/33/8/3241.full
SO  - Anticancer Res2013 Aug 01; 33
AB  - Background/Aim: Data on the clinicopathological features and prognostic impact of c-N-Methyl-N’-nitro-N-nitroso-guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET and HGF expression in 49 patients with early-stage HCC and correlated the results with disease characteristics and survival. Materials and Methods: Expression of c-MET and HGF mRNA in tumor (T) and non-tumor (NT) tissues was assessed. Results were correlated with patient characteristics and overall and recurrence-free survival. Results: Median relative tumor c-MET and HGF expressions were 3.23 (T/NT ratio 6.46) and 9.07 (T/NT ratio 0.77), respectively. c-MET and HGF were overexpressed in early-stage disease with favorable characteristics although there was no association with survival. Conclusion: Contrary to other studies, in our series increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival. The prognostic and therapeutic applications of this knowledge to HCC are under active investigation.