PT  - JOURNAL ARTICLE
AU  - TSUTOMU KAWAGUCHI
AU  - SHUHEI KOMATSU
AU  - DAISUKE ICHIKAWA
AU  - TAKESHI KUBOTA
AU  - KAZUMA OKAMOTO
AU  - ATSUSHI SHIOZAKI
AU  - HITOSHI FUJIWARA
AU  - HIROTAKA KONISHI
AU  - RYO MORIMURA
AU  - YASUTOSHI MURAYAMA
AU  - YOSHIAKI KURIU
AU  - HISASHI IKOMA
AU  - MASAYOSHI NAKANISHI
AU  - CHOHEI SAKAKURA
AU  - EIGO OTSUJI
TI  - Comparison of Prognostic Compatibility between Seventh AJCC/TNM of the Esophagus and 14th JCGC Staging Systems in Siewert Type II Adenocarcinoma
DP  - 2013 Aug 01
TA  - Anticancer Research
PG  - 3461--3465
VI  - 33
IP  - 8
4099  - http://ar.iiarjournals.org/content/33/8/3461.short
4100  - http://ar.iiarjournals.org/content/33/8/3461.full
SO  - Anticancer Res2013 Aug 01; 33
AB  - Background and Aim: The Seventh American Joint Committee on Cancer (AJCC)/TNM classification defined that the classification for adenocarcinoma of the esophagogastric junction (AEG) was included in the esophageal category. However, there still remain various classifications in AEG such as the Seventh AJCC/TNM of the esophagus and the 14th Japanese Classification of Gastric Cancer staging system (JCGC) in Japan. This study was designed to evaluate the compatibility of both the Seventh AJCC/TNM of the esophagus and the 14th JCGC staging systems in Siewert type II adenocarcinoma. Patients and Methods: Between 1999 and 2011, 47 consecutive patients with Siewert type II adenocarcinoma underwent curative surgery at our Institution. We reviewed their hospital records retrospectively. Results: Overall survival rates at 3 and 5 years were 44.3% and 33.4%, respectively. Multivariate analyses revealed that the extent of lymph node metastasis was the only independent prognostic factor (p=0.0194, HR=12.927). In the ≤pN2 group by 14th JCGC, deeper tumor depth was significantly correlated with poor prognosis, whereas in the ≥pN3 group, deeper tumor depth did not affect prognosis, suggesting a strong effect of nodal factor on prognosis and more similar prognostic stratification to the Seventh edition of the AJCC/TNM classification of the esophagus. Conclusion: Nodal involvement status might be a more important prognostic factor than tumor depth in patients with Siewert type II adenocaricinoma. The Seventh classification of AJCC/TNM of the esophagus might be more compatible with Siewert type II adenocarcinoma.