RT Journal Article
SR Electronic
T1 The Effect of Surgical Wound on Ovarian Carcinoma Growth in an Animal Model
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3177
OP 3184
VO 33
IS 8
A1 JEONG-WON LEE
A1 YOUNG-AE PARK
A1 YOUNG-JAE CHO
A1 KYU-HO KANG
A1 JUNG-JOO CHOI
A1 YOO-YOUNG LEE
A1 TAE-JOONG KIM
A1 CHEL HUN CHOI
A1 BYOUNG-GIE KIM
A1 DUK-SOO BAE
YR 2013
UL http://ar.iiarjournals.org/content/33/8/3177.abstract
AB Background/Aims: We examined the effects according to the extent of surgical wound mimicking laparoscopy or laparotomy on ovarian cancer growth in an orthotopic mouse model. Materials and Methods: To mimic surgery effects, we performed laparoscopy or laparotomy on athymic nude mice under isoflurane inhalation at four days after tumor cell injection. For the laparoscopy model, we performed pneumoperitoneum with CO2, by inserting three cannulars. Results: Mice in the laparoscopy-mimicking group had significantly lower tumor weight compared to mice in the laparotomy group (p<0.05). In the immediate postoperative period, serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP2) were significantly lower in the laparoscopy group. Conclusion: These results indicate that a minimal surgical wound such as that on laparoscopy, appears to induce little surgical stress on enhancing tumor growth compared to laparotomy in an ovarian cancer animal model, possibly because it minimally influences the secretion of VEGF and MMP2.